NQO1 binds many IDPs, including p53, p73α and monomer ODC, and protects them from 20S proteasomal degradation by a mechanism requiring NADH 11. While NQO1, a 20S proteasome gatekeeper ...

为解决食管癌放疗抵抗问题，研究人员开展了关于 ROBO1 在食管癌放疗抵抗中作用机制的研究。结果发现 ROBO1 通过加速 G3BP2 介导的 eIF3A 降解，中断 P53 翻译，激活 mTOR 信号，增强癌细胞放疗抵抗。该研究为克服食管癌放疗抵抗提供了新靶点 128 。

This allows p53 degradation and explains the low concentrations of p53 found in these groups. MDM2-phospho-p53 complexes were observed in COPD but not in the other samples. This correlates with ...