引言癌症背后的分子机制一直是科学研究的热点。在癌症的众多驱动因素中，TP53基因被誉为“基因组的守护者”，是人类体内最重要的肿瘤抑制基因之一。然而，这位“守护者”也常常成为癌症发展的“叛徒”，数据显示，大约50%的癌症患者都携带TP53基因的突变。这 ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

Discover recent research that sheds light on a promising therapeutic strategy for tackling prostate cancer by targeting the ...

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

A research team from the University of Konstanz has now shown that different mutations have different effects on cell metabolism. In the case of DNA damage, the p53 protein has the task of ...

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease. This unexpected discovery could help doctors identify which ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

INR:9979. game khelne wala Clinical trials of potential new drugs targeting p53 mutations begin Hainan Provincial Market Supervision Bureau: whistleblowers sente ...