germline Li-Fraumeni mutations and germline p53 polymorphisms. The tumour-associated mutations in sporadic cancers arise in somatic cells, both spontaneously and as a consequence of DNA damage.

A research team from the University of Konstanz has now shown that different mutations have different effects on cell metabolism. In the case of DNA damage, the p53 protein has the task of ...

p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

After receiving this validation, we developed panels of guide RNAs for generating targeted mutations in the p53 tumour-suppressor gene. More than half of all cancers have mutations in p53 that ...

They suggest that if a person with Barrett's oesophagus has an early CDKN2A mutation but no mutations in p53, it could indicate that their condition is less likely to progress to cancer.

FMC-220 is a first-in-class covalent activator of p53Y220Cdesigned to address potency and tolerability challenges of non-covalent approachesIn ...

P53 Overexpression and mutation seen in children ... mixed picture with sequencing analysis Mutations or deletions common (at least >50%) MGMT Increased expression and less frequent epigenetic ...

Frontier Medicines Corp. has announced the selection of FMC-220, a first-in-class covalent small-molecule activator of p53 Y220C designed to address potency and tolerability challenges of noncovalent ...

p53 is often referred to as the “guardian of the genome” due to its critical role in maintaining genomic stability, but it can be altered in cancer with mutations such as Y220C. The Y220C ...