点击蓝字关注我们【导读】神经母细胞瘤（NB）是一种常见的儿童恶性实体肿瘤，预后不佳。尽管已有研究表明香菇多糖（LNT）具有抗肿瘤功效，但其对神经母细胞瘤发挥抗肿瘤作用的分子机制仍不清楚。3月15日，广州医科大学/南京医科大学合作共同在期刊《Cell ...

在辐射诱导衰老的 IMR90 人成纤维细胞实验中，敲低 p53 会使 CCF 形成显著增加，而激活 p53，无论是通过外源性表达 p53，还是抑制 MDM2（MDM2 是 p53 的负调控因子），都能有效抑制 CCF 的形成。此外，MDM2 抑制剂（MDM2i）对 CCF 形成的抑制作用依赖于 p53，且这种抑制 ...

鼠双微体 2（MDM2）是一种 E3 泛素连接酶，主要作为 p53 肿瘤抑制蛋白的负调节因子被熟知。但它也具有 p53 非依赖性功能，通过转录、翻译后修饰、蛋白质降解、与辅助因子结合和亚细胞定位等多种机制调节其他靶标，参与细胞周期调控、应激反应和神经元可塑 ...

Furthermore, Mdm2 not only functions as an E3 ligase in the degradation of p53, but is also involved in exporting p53 out of the nucleus before its degradation.

Researchers from Walter and Eliza Hall Institute of Medical Research, The University of Melbourne and affiliated organizations presented the development of a new reporter mouse model designed to study ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

It also develops APG-2575, an oral administered Bcl-2 selective inhibitor for hematologic malignancies and solid tumors; APG-115, an oral small molecule inhibitor of the MDM2-p53 protein-protein ...