为探究胰腺癌（PDAC）表型异质性的遗传机制，研究人员开展 MYC ecDNA 研究，发现其促进肿瘤异质性和可塑性，意义重大。 胰腺癌（Pancreatic Ductal Adenocarcinoma，PDAC）作为一种恶性程度极高的消化系统肿瘤，其预后极差，5 年生存率仅约 10%。在胰腺癌的发生发展过程中，MYC 基因的异常扩增与肿瘤的侵袭性和不良预后密切相关。MYC ...

撰文 | 冉茂双 责编 | 周叶斌MYCN的异常表达与多种人类癌症的肿瘤发生密切相关，其中MYCN扩增是高危神经母细胞瘤 (NB) 的主要遗传驱动因素，也是临床上最强的独立不良预后因素。MYCN基因编码致癌转录因子N-Myc在正常神经前体细胞中泛素化 ...

2025年2月18日，一篇新的研究论文发表在Oncotarget，第16卷，题为“端粒酶永生人类细胞中强大的p53表型和潜在的下游靶标”。 2025年2月18日，《Oncotarget》杂志第16卷发表了一篇题为“端粒酶永生化人类细胞中稳健的p53表型及潜在下游靶点”的研究论文。来自西德尼 ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

The MYC family of proteins ... studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent and p53-independent oncogenic activities in various cancers.