该文旨在探究lncRNA-IUR在喉鳞癌（LSCC）中的作用。结果表明IUR在LSCC中下调。IUR的低表达水平与LSCC患者的低生存率相关。过表达实验表明，IUR过表达导致LSCC细胞中p53表达水平升高，miR-24过表达导致p53表达水平降低。

为探究 CHI3L1 在结直肠癌（CRC）放疗抗性中的作用，研究发现其可促癌细胞增殖等，为治疗提供新思路。 在癌症治疗的广阔领域中，结直肠癌（Colorectal Cancer，CRC）一直是困扰全球医学界的难题。它作为常见的胃肠道恶性肿瘤，严重威胁着人类的健康。放疗，作为 CRC 综合治疗的重要一环，对于延长患者生存期、降低局部复发率起着关键作用，尤其是在直肠癌的治疗中，其地位更是不可替代。然而 ...

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.

When p53 malfunctions, the result is often cancer. Learning about how p53 works has not only deepened how scientists ...

The groups interested in studying p53 next wanted to investigate its interactions with T antigen. Scientists made these findings as the theory of oncogenes, the idea that mutated host growth-promoting ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

A comparison of patients with and without BRCA gene mutations receiving prophylactic risk-reduction surgery suggest ...

In this interview, Dr. Christian Schafmeister discusses the structural advantages of Spiroligomer molecules, their ability to ...

Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468(7323):572-5. 5. Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...