A recent study suggests that p63 may be key, at least for many epithelial stem cells. As diverse as the coats in a fashion boutique, epithelia are the cellular cloaks of our body and its many organs.

为探究口腔扁平苔藓（OLP）发病机制及恶性潜能，研究人员通过对 20 例 OLP 患者和 10 例健康对照进行免疫组化分析，检测 p53、p63、bcl-2、Ki-67 和 COX-2 水平。结果发现 p63 表达显著降低，未发现病变恶性潜能增加的分子证据，为 OLP 研究提供新方向。 口腔扁平苔藓 ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

it took some time for scientists to realize that all four papers described the same protein. Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this ...