PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...

[19] Potentially important platelet mediators include platelet-derived growth factor (PDGF), TGF-beta 1 ... matrix degradation, chemotaxis, retinoid loss, and WBC chemoattraction.

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...