Platelet-derived growth factor subunit B (PDGFB), also known as FLJ12858, PDGF2, SIS, SSV, and c-sis, belongs to the PDGF family. It can form either a homodimer (PDGF-BB) or a heterodimer with the ...

PDGF and its receptors are implicated in tumorigenesis and angiogenesis, prompting Sebti and colleagues to design a synthetic molecule, called GFB-111, that binds to PDGF. Their new molecule has ...

Expert Rev Ophthalmol. 2013;8(6):527-537. Protein kinase C-mediated contraction of RPE cells is stopped by an anti-PDGF antibody. Unfortunately, blocking PDGF is ineffective at suppressing PVR in ...