News Medical on MSN1d
Study uncovers molecular mechanisms behind insulin resistance in skeletal muscle
Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...
EurekAlert!1d
New molecular mechanisms linked to insulin resistance
Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high ...
Nature15d
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear receptor that has a critical role in adipogenesis, glucose metabolism and placental function 1,2,3.
Nature4y
Highly potent PPAR-α agonist versus standard therapy in patients with lipid disorders
Fibrates are widely prescribed agonists of transcription factor peroxisome proliferator-activated receptor (PPAR)-α, and are used to treat patients with atherogenic dyslipidemia. These drugs ...
Hosted on MSN1mon
Omvoh Approved for Crohn's; Fitbit Predicts IBD Flares; H. Pylori and Gastric Cancer
The investigational pan-peroxisome proliferator-activated receptor (PPAR) agonist lanifibranor showed promise in a phase II study of MASLD patients with diabetes. (Journal of Hepatology ...
News Medical on MSN14d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
Hosted on MSN1mon
FDA grants ODD to Tempest’s hepatocellular carcinoma treatment
The US Food and Drug Administration has granted orphan drug designation (ODD) to Tempest Therapeutics' oral, selective peroxisome proliferator-activated receptor alpha (PPAR-α) antagonist ...