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在微观的细胞宇宙中，一个名为PTEN（Phosphatase and tensin homolog）的蛋白质如同精密的分子刹车，时刻调控着细胞增殖与存亡。这个仅有403个氨基酸的"生命守护者"，通过拮抗PI3K/AKT/mTOR信号通路，在胚胎发育、突触可塑性乃至肿瘤抑制中扮演关键角色。然而令人惊讶的是，尽管30%的癌症和多种神经发育疾病（如自闭症、癫痫）与PTEN功能异常密切相关，研究人员却长期 ...

研究人员将目光聚焦于膀胱癌中常见的 p53 突变。在膀胱癌里，超过60%的 p53 突变属于错义突变，然而此前多数小鼠模型是 p53 基因敲除模型，针对 p53 ...

为明确 PTEN 错构瘤肿瘤综合征（PHTS）中非成分癌症（NCC）情况，研究人员开展相关研究，发现其 NCC 谱，具重要意义。 PTEN 错构瘤肿瘤综合征（PTEN hamartoma tumor syndrome，PHTS）听起来或许有些陌生，但它却与多种癌症的发生息息相关。PHTS 是一类由致病的种系 PTEN ...

为解决无法在完整生物系统中直接监测 PTEN 活性的问题，特拉维夫大学研究人员开展基于 FRET 的生物传感器相关研究。他们开发出能在体内动态成像 PTEN 活性的传感器，这对探究相关疾病机制和开发疗法意义重大，推荐科研读者阅读。 在细胞的世界里，有一个 ...

Arizona State Retirement System reduced its position in shares of Patterson-UTI Energy, Inc. (NASDAQ:PTEN – Free Report) by 1 ...

In a report released on March 10, Saurabh Pant from Bank of America Securities maintained a Buy rating on Patterson-UTI (PTEN – Research ...

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