X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

The disease seems to occur in one of two patterns ... right infraorbital fissure, right maxillary bone, lacrimal bone, malar process and zygomatic bone. These bones were soft, suggesting that ...

A young woman from Los Angeles suffered intense pain in her leg to the point she could not walk before being diagnosed with a ...

PRISM (Paget's disease Randomized trial of Intensive versus Symptomatic Management) was a pragmatic randomized controlled trial, designed to compare the effects of intensive bisphosphonate therapy ...

Osteoporosis is common in older adults, especially females and happens due to loss of bone mineral density. Whereas, Paget disease involves thickened and weaker-than-normal bone. The cause is not ...

Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early research shows that taking ipriflavone might decrease bone pain in some ...