City of Hope researchers demonstrate proof of concept for a novel targeted therapy for pancreatic cancer, exploiting transcription-replication conflicts to combat treatment resistance.

Microscope image of mouse pancreatic tissue, with insulin-producing tissue marked in brown. Early-life exposure to a specific gut microbe appears to boost growth of insulin-producing tissue ...

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S.

A new study focused on transcription-replication conflicts, which occur when mechanisms responsible for gene expression and ...

Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it's diagnosed, it's often ...

This intrigued Andersson-Rolf, who noted that LGR5 is present in human pancreatic stem cells but absent in mice, underscoring a key difference between human and mouse pancreatic development. This ...

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic “marks” in a transition state between ...

Researchers have identified a new molecular target for treating pancreatic cancer. Scientists focused on transcription-replication conflicts (TRCs), which occur when the mechanisms responsible for ...

Researchers at City of Hope have identified a new molecular target for treating pancreatic cancer, reports a Gastroenterology ...

A preclinical model developed at UT Southwestern Medical Center that recapitulates a rare infant-onset form of diabetes ...