CD47 is an immune checkpoint protein that functions as a regulator of phagocytosis. Cancer immunotherapies that target adaptive immune checkpoints have demonstrated clinical benefits in a range of ...

Inefficient removal of dying cells results in human autoimmune and inflammatory diseases. On the other hand, targeted phagocytosis of cancer cells has recently been developed as a cancer treatment ...

The team then tested a battery of existing drugs on the microglia, to see if any might restore phagocytosis. They found one: ADH-503, also known as GB1275—an experimental oral pancreatic cancer ...

More details about the programs for the AACR Annual Meeting 2025 are available online at AACR Annual Meeting 2025 | Meetings ...

The white blood cell then engulfs the pathogen in a process called phagocytosis, in which it "eats" the foreign invader to neutralize it. This dramatic process might sound like something out of a ...

Bispecific antibodies first reached patients as cancer treatments ... The drug leads to depletion of these cells via phagocytosis, a process in which an immune cell engulfs a pathogen, eliminating ...

LTZ-301 works by redirecting monocytes and macrophages toward CD79b+ B-cells, leading to enhanced phagocytosis and depletion of cancer cells. The initial study of LTZ-301 will be conducted in ...

PARIS, France I March 20, 2025 I Sanofi and Dren Bio, Inc., a private clinical-stage biopharmaceutical company, have entered into a definitive agreement under ...