Figure 1: Mating scheme of ENU-mutagenesis protocols in the mouse. Phenotype-driven approach. The most crucial factor for ENU mutagenesis is a reliable phenotyping platform, which must ensure ...

Mouse phenotyping studies analyse biological properties, such as the evolution of disease symptoms, in mice that have had a specific gene modified, added or removed. “We live in an ageing ...

The Mouse Metabolism and Phenotyping Core is a comprehensive fee-for-service rodent phenotyping core providing investigators with a wide variety of state of the art equipment and techniques. We work ...

Rationale.The central nervous system (CNS) is the most complex structure of the animal organism both in terms of its development and function. CNS phenotyping requires special skills and equipment, ...

Colossal Biosciences has altered several genes in mice to make them look more mammoth-like, but the company is far from its goal of fully resurrecting woolly mammoths by 2028 ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

Though the approach is relatively simple, many researchers struggle with understanding the complexities associated with the diverse alleles that can be generated, how to deal with mosaicism, and how ...

Read more A radical new theory rewrites the story of how life on Earth began "The work done on these mice does not mean that there is a ready solution to bring back a mammoth phenotype," says team ...