Greater than 50 mg/L: coma and seizures. Our patient had serum levels in excess of 40 mg/L and presented to us in stupor. Miller et al noted that the CNS was affected in six (27%) of the 22 ...

The recovery of phenytoin from mixtures containing different phenytoin formulations and protein mixtures was studied. Three phenytoin solutions (40 mg/µL) were prepared, each in triplicate, from ...

Phenytoin dosing was analysed in fifty-one patients. 67% of patients were loaded correctly (20 mg/kg) according to the local guideline, 31% were given a lower dose than recommended and only 2% were ...

Alderhey.nhs.uk Introduction Phenytoin has complex pharmacokinetics. The intravenous loading dose of phenytoin for children in status epilepticus has recently been increased from 18 to 20 mg/kg. There ...

One patient had a serum phenytoin level of 65.8 mg/L. Conclusion 68% of patients on long–term phenytoin complained of poor balance and 52% had clinical evidence of ataxia. Cerebellar abnormalities on ...

Phenytoin BP tablets manufactured by Regent Laboratories (now withdrawn) had a relative bioavailability of only 76% compared with tablets manufactured by A H Cox and Company. In vitro dissolution ...