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Palisade Bio begins MAD cohorts of Phase Ia/b ulcerative colitis therapy trial
The study's primary goal is to assess the therapy’s tolerability, pharmacokinetics and safety in healthy volunteers.
Nuance Pharma Announces Approval of Ohtuvayre™ (ensifentrine) in Macau SAR, China
Nuance Pharma ("Nuance") announced that the Pharmaceutical Administration Bureau Macau approved Ohtuvayre™ (ensifentrine) for the maintenance treatment of chronic obstructive pulmonary disease (COPD) ...
Nature5y
Enhancing cognition through PDE4 regulation
The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...
Medscape6d
Phosphodiesterase Inhibitors in Clinical Urology
The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular and vascular penile ...