Negative (and positive) selection in such a system never ... If negative selection is too weak to remove harmful mutations, then deleterious mutation accumulation will occur, and a gradual decay ...

PolyPhen-2 calculates the naive Bayes posterior probability that a given mutation is damaging and reports estimates of false positive (the chance that the mutation is classified as damaging when ...

The appraisal committee has prepared final draft guidance (FDG) on olaparib for treating BRCA mutation-positive HER2-negative metastatic breast cancer after chemotherapy (Review of TA762) [ID6336] and ...

The former NBC news anchor, 49, revealed last month in an Instagram post that she had tested positive for the BRCA1 gene mutation, putting her at a higher risk for breast and ovarian cancer.

This treatment effect was statistically significant ( p=0.01) in all subjects, regardless of mutation at two years, validating the gene-agnostic mechanism of action for OCU400. This data ...

reported positive topline results from a Phase 3 study of its drug Braftovi, also known as encorafenib, in the treatment of a certain type of colorectal cancer. The study, called BREAKWATER, evaluated ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...