Preferentially expressed antigen in melanoma (PRAME) is a protein that has gained attention in the field of cancer immunotherapy, particularly for its role in diagnosing and differentiating ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones ... particularly in ferroptosis-related pathways. A key discovery was the activation of the HIF1α-HMOX1 ...

focuses on training T-cells to target cancer, with a promising pipeline led by IMA203 targeting PRAME in solid tumors. IMA203 shows a 54% response rate in metastatic melanoma; phase 3 SUPRAME ...

Although melanoma only represents around 6% of skin cancers, it is responsible for more than 80% of skin cancer-related deaths ... triggering different molecular pathways. This study found ...

To elucidate DNA damage response in human breast, skin and skin melanoma, this study applied an integrative approach which included classical genomic, microarray and refined computational systems ...