Selecting an appropriate mouse model is one of the most important decisions a pre-clinical researcher can make. Which is best suited for immuno-oncology? Cancer research and drug discovery has ...

Established in 2002, the Animal and Preclinical Models Core serves to provide specialized capabilities for developing and characterizing numerous CF animal models relevant to CF pathogenesis and ...

The consensus report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee. Cancer Res 64 : 2270-2305. Kaplan-Lefko P, Chen T, Ittmann M, Barrios R, ...

Most clinically relevant T-cell receptor (TCR)-engineered T cells are typically tested in immunocompromised mice, allowing human T-cell engraftment but failing to replicate the complex interactions of ...

A research team has investigated a new combination therapy against cancer. This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod.

Explore the applications of preclinical MRI in neurological diseases, focusing on functional and metabolic imaging techniques ...

In a recently published study about the new compound, called CNDR-51997, the team found it was effective in restoring brain health in mouse models ... neuronal loss. In preclinical studies ...

A breakthrough study highlights Xenon gas as a potential game-changer in treating Alzheimer’s disease, demonstrating its ...

A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical ...