The protein folding machinery of the endoplasmic reticulum is coupled to the burden of unfolded proteins by an unfolded protein response (UPR) that promotes rectifying transcriptional and ...

The endoplasmic reticulum (ER) is the primary site of protein folding and processing. When IECs experience high secretory ...

ER is recognized for recombinant protein localization as it houses molecular chaperons that aid protein-folding and also minimizes risks of protein degradation. Proteins directed towards the ER ...

Caption The three endoplasmic reticulum (ER) stress sensors (PERK [red], IRE1 [blue], ATF6 [green]) initially activate signaling events that increase protein-folding capacity and reduce protein ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...