Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

A self-cleaving element for use in bioseparations has been derived from a naturally occurring, 43 kDa protein splicing element (intein) through a combination of protein engineering and random ...

Proteins serve as the fundamental components of life, composed of folded peptide chains made up of a sequence of amino acids.

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Their diversity is further increased by modifications that take place after the peptide chains have been synthesised. One form of modification is protein splicing. The protein initially contains a ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

One form of modification is protein splicing. The protein initially contains a so-called ‘intein’, which removes itself from the peptide chain to ensure the correct folding and function of the ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...