Much of the difficulty of determining the contributions of individual residues to protein structure and function stems from the need to generate and evaluate a large number of mutants. The ...

Our brain's remarkable ability to form and store memories has long fascinated scientists, yet most of the microscopic ...

Proteins are fundamental biomolecules that perform a broad range of vital functions within the human body. They serve as an essential structural and functional component of cells, tissues and organs ...

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that ...

Their work suggested that this new function of RAD52 facilitates the survival of cancer cells. In the new study, Spies’ team used cryogenic electron microscopy (CryoEM) to show that RAD52 proteins ...

Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the sequence-structure-function relationship, particularly ...

Identifying a key protein’s role in benzodiazepine-related side effects could improve the common mental health medications ...

The information DNA contains is the instructions that the cell uses to make proteins. Proteins play a big part in determining the characteristics of specialised cells and whole organisms.

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question.

In Greek mythology, Proteus, son of Poseidon and prophetic shepherd of sea-beasts, could foretell the future. The elusive sea god was difficult to capture as he assumed many forms—a lion, a serpent, ...

RAD52 has already shown promise as a drug target. Inhibitors of the protein can selectively kill cancerous cells while sparing healthy ones, reducing the collateral damage typically caused by ...

“Our structure ... the PINK1 protein, which supports cell survival by detecting damaged mitochondria and tagging them for removal. “PINK1 is a ubiquitin and Parkin kinase and functions ...