In living organisms, every protein—a type of biological polymer consisting of hundreds of amino acids—carries out specific ...

In 1961 the structure of one protein, myoglobin, was known at 6 Å resolution and its 2 Å structure would soon be published. The structural determinations of hemoglobin and hen lysozyme were well ...

Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...

Usually, scientists visualize protein folding with the help of molecular dynamics (MD) simulations, which model the physical movement of the atoms in the folding protein and the water surrounding it.

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded ...

If proteins fail to find their partners or fold incorrectly ... focuses on the fundamental principles governing protein ...

I studied the structure of granulins, which are cysteine rich proteins implicated in neurodegenerative diseases. To verify protein folding, I conducted an assay so often that I created a templated, ...

Prof. Göpfrich's work starts with the question of how synthetic cells can be created that bypass protein synthesis, which is essential in living cells. She uses the technique of RNA origami, which is ...

One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible ... for example—is translated using self-folding RNA alone. First, a DNA sequence is designed ...

Prof. Göpfrich’s work starts with the question of how synthetic cells can be created that bypass protein synthesis, which is essential in living cells. She uses the technique of RNA origami, which is ...