Cells sustain their purine levels through two pathways: De novo synthesis builds purines from scratch, whereas the salvaging route uses intermediate metabolites, such as those obtained from the diet.

Recent research has focused on understanding the roles of different enzymes involved in nucleotide metabolism, particularly in the context of purine and pyrimidine nucleotide biosynthesis and ...

GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of purine nucleotides in cells. Disorders of purine metabolism can lead to ...