来自国际团队的研究人员揭示了BRCA2缺失导致PARP抑制剂(PARPi)敏感性的分子机制。研究发现BRCA2通过阻止PARP1在DNA损伤位点的异常滞留，保护RAD51丝免受PARPi干扰，阐明了"合成致死"效应的关键环节，为BRCA2突变肿瘤的靶向治疗提供新见解。 肿瘤抑制蛋白BRCA2在DNA同源 ...

RAD51 is a protein involved in homologous recombination repair (HRR) alterations. Developed in-house by Serra's laboratory, the RAD51 assay is based on the detection of this protein as a ...

The genes VEGFA, BRCA1, RAD51, CCNB1, CHEK1 ... In vitro validation further supported their overexpression in breast cancer, suggesting their importance in molecular landscape of the disease ...