来自国际团队的研究人员揭示了BRCA2缺失导致PARP抑制剂(PARPi)敏感性的分子机制。研究发现BRCA2通过阻止PARP1在DNA损伤位点的异常滞留，保护RAD51丝免受PARPi干扰，阐明了"合成致死"效应的关键环节，为BRCA2突变肿瘤的靶向治疗提供新见解。 肿瘤抑制蛋白BRCA2在DNA同源 ...

RAD51 is a protein involved in homologous recombination ... cancer associated with deficiency in this DNA damage repair (DDR) pathway. Functional assays that can detect dynamic changes in HRR ...

The primary job of BRCA2 is to regulate RAD51, a key player in the accurate ... maintaining the integrity and function of DNA repair pathways. “Cancer cells can somehow tolerate the loss of ...