First, like Ras, Rho family proteins serve as guanine nucleotide-regulated binary switches that control signaling pathways that ... as critical regulators of oncogenic Ras transformation.

When one of the proteins in the pathway is mutationally activated, it can drive tumor development and growth. RAS is the most frequently mutated oncogene in cancer, with KRAS mutations occurring ...

Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ERK activation. The combination of Hsp90 inhibitors with RAF or MEK inhibitors may achieve a better pathway inhibition ...