Here we review the technical improvements being ... the precise minimum sequence length to achieve strong RNA interference is not yet known. Most studies utilize dsRNA that is greater than 500 ...

Efficient RNA interference in Caenorhabditis elegans ... chromosome segregation and genome editing (see ref. 3 for a review). First, secondary siRNA has a 5′ triphosphate, precluding cloning ...

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of ...

In 1998, Andrew Fire and Craig Mello published a groundbreaking study demonstrating that double-stranded RNA (dsRNA) could silence genes in the nematode Caenorhabditis elegans. This discovery laid the ...

Despite growing competition in the transthyretin amyloid cardiomyopathy (ATTR-CM) field, Alnylam is hoping its RNA interference approach can set it apart from its peers. And now, the Massachusetts ...