What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

This disruption leads to abnormal RNA processing and splicing errors. Further analysis revealed that these irregularities align with widespread gene disruptions, particularly in the striatum ...

The resulting primary transcript, known as pre-mRNA in eukaryotes, undergoes several processing steps before becoming a mature mRNA molecule ... Other ribozymes include self-splicing introns and the ...