Charles Sawyers and colleagues have conducted a small early-stage clinical study to assess target modulation by the small-molecule inhibitor rapamycin. Rapamycin is approved to treat renal cancer ...

研究人员为明确 TFEB 核穿梭调控机制，用微流控和定量建模研究，揭示其动态变化，意义重大。 在细胞的微观世界里，营养物质的充足与否时刻影响着细胞的 “决策”，其中转录因子 EB（TFEB）起着关键作用。TFEB 是 MiT/TFE 家族的一员，作为溶酶体生物发生和自 ...

Rapamycin, a natural compound, has shown anti-aging and health benefits in various researches. Consequently, the popularity and demand for rapamycin supplements have surged significantly in the ...

In particular, the mechanistic target of rapamycin (mTOR) pathway has been tied to multiple age-related chronic disease processes, such as declining immune function, diminishing bone mineral ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...