A new small-molecule inhibitor may put the brakes on Ras by inhibiting the deacylation enzyme APT1. Figure 1: Palmostatin B, a newly described inhibitor of the deacylating enzyme APT1, enhances ...

Hundreds more papers describe the use of analogous dominant-inhibitory versions of Ras-related GTP-hydrolysing enzymes, or GTPases, and the number of such papers continues to grow. It thus seems a ...

On a hunch, the team tested a dozen drugs that target K-Ras against a handful of GTPases ... "In the case of these enzymes, it was critical for us to first test our ideas experimentally in the ...