Once activated, Ras can do a variety of things. In this example, it activates an enzymatic cascade of MAP kinases ... activates an enzyme called a kinase. Learn how kinases initiate a signaling ...

The phosphoinositide 3-kinase (PI3K ... and oncogenes such as RAS to multiple essential cellular functions. The PI3K pathway is tightly controlled by a class of PI3Ks that generate the lipid ...

Vividion Therapeutics has dosed the first subject in a Phase I trial of an oral inhibitor, VVD-159642, aimed at treating ...

The results demonstrate that compared to avutometinib alone, the FAK inhibitor/avutometinib combination inhibits RAS/MAPK pathway signaling more deeply while also blocking key adaptive resistance ...

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK ...

The mitogen-activated protein kinase (MAPK) pathway is a central signaling cascade ... it can drive tumor development and growth. RAS is the most frequently mutated oncogene in cancer, with ...

Title: QTX3544, a potent and selective G12V-preferring KRAS inhibitor, synergizes with EGFR inhibitors for enhanced anti-tumor activity Session Name: Late-Breaking Research: Experimental and Molecular ...