First, like Ras, Rho family proteins serve as guanine nucleotide-regulated binary switches that control signaling pathways that in turn regulate diverse cellular processes. Rho family proteins are ...

Farnesylated and palmitoylated Ras proteins (P, F) then enter the secretory vesicular pathway for transport to the plasma membrane (PM), where their dual lipid modifications enhance association.

Title: QTX3544, a potent and selective G12V-preferring KRAS inhibitor, synergizes with EGFR inhibitors for enhanced anti-tumor activity Date and Time: Wednesday, April 30, 2025; 9:00 AM - 12:00 PM ...

A single cellular pathway helps drive almost one in four cancers. After 40 years, scientists may have finally found a way to target the mutant protein that kicks it into overdrive. This article ...

The results demonstrate that compared to avutometinib alone, the FAK inhibitor/avutometinib combination inhibits RAS/MAPK pathway signaling ... family of non-receptor protein tyrosine kinases.

A Deep Cyclic Inhibitor (DCI) of the mitogen-activated protein kinase (MAPK) pathway, IMM-6-415 ... kirsten rat sarcoma (KRAS), neuroblastoma RAS (NRAS), or Harvey RAS (HRAS) mutant solid tumours ...