Purpose: The pharmacology, pharmacokinetics, clinical efficacy, and safety of rasagiline are reviewed. Summary: Rasagiline is a novel, investigational propargylamine that irreversibly and ...

Recently, rasagiline has been shown to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an enzyme that catalyzes the sixth step of glycolysis and participates in the initiation of apoptosis.

Am J Health Syst Pharm. 2006;63(10):915-928. Results of this study suggest that adjunctive rasagiline significantly reduces off time with efficacy similar to that observed by adding entacapone to ...