The model has been able to closely recapitulate human in vivo proximal tubule functionality and generated valuable insights regarding drug transport by primary human kidney cells. In my opinion ...

During this project we generated kidney transporter cell models using well-characterized hTERT-immortalized renal proximal tubule epithelial cells 2 (RPTEC/TERT1) that stably overexpress the OAT1 ...

Customers can use the freshly isolated proximal tubule cell kidney transporter model in their own lab to better understand possible cross-species differences in drug handling using Newcells ...

A new research paper was published in Volume 16, Issue 22  of Aging (Aging-US) on December 20, 2024, titled, “Impaired renal ...

Especially drug transporters of the small intestine, liver and kidney are major determinants of the pharmacokinetic profile of drugs. Transporter-mediated drug–drug interactions in these three ...

Acute kidney injury (AKI) may progress to chronic kidney disease, and there is an urgent need for approaches that improve the limited regeneration of the renal tubules after AKI.

Tubular glucose reabsorption is performed by the combined action of Na + /D-glucose SGLTs co-transporters ... kidney energy needs; and glucose reabsorption from proximal convoluted tubule.