Single nucleotide polymorphisms (SNPs) are major contributors to genetic variation, comprising some 80% of all known polymorphisms, and their density in the human genome is estimated to be on ...

For a given population, both intrinsic population-genetic properties and the properties of genomic resources affect the utility of tag SNPs and the performance of genotype-imputation methods.

IBG researchers make use of well-characterized longitudinal data arising from both family-based and population-based samples. Statistical and epidemiological approaches being used at IBG include ...

This section covers Twin and SNP heritability, h2 from whole genome sequencing, non-additive genetic effects and GWAS approaches. To better compare and understand the different approaches and models ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

Where genes are associated with CD and UC, the p-values are given from the index gene discovery study; this is CD for all the genes presented here. * Colonic CD only. ‡ Early-onset disease ...