In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. Conclusion. Our findings provide further support for apigenin and ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

We found that driving a prolonged interferon/STAT1 response, particularly in the neurons of the basal ganglia, which has been implicated in ADHD, was sufficient to cause hyperactivity in mice.” ...

调节性T细胞是维持机体免疫稳态的CD4+ T细胞亚群，也是肿瘤微环境中免疫抑制屏障的主要构成细胞。因此，特异性地调控肿瘤微环境的Treg细胞使其功能与稳定性发生改变，将能够促进肿瘤杀伤反应的发生。

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in ...

All in all, the above data suggest that apigenin and luteolin treatment regulates STAT1 at the level of phosphorylation and prevents the necessary signaling, in response to IFN-γ, required to ...