In addition to tocilizumab, sarilumab, another IL-6 receptor blocker, has also been evaluated for its effectiveness in patients experiencing relapses during glucocorticoid tapering. A recent study ...

Kevzara (sarilumab) may be used in combination with methotrexate for moderately to severely active disease, in patients intolerant to one or more disease-modifying anti-rheumatic drugs.

The Food and Drug Administration (FDA) recently approved the biologic drug sarilumab (Kevzara) for the treatment of rheumatoid arthritis (RA). Sarilumab blocks a protein called interleukin-6 (IL-6), ...

Background Sarilumab is a human mAb blocking the IL-6Rα. In the phase 3 TARGET study (NCT01709578), sarilumab (150 or 200 mg SC q2w) + csDMARDs demonstrated efficacy in adults with active, moderate-to ...

We have previously reported results obtained in 15 OG patients treated with TCZ where a decrease in mean CAS from 4.9 to 1.7 was observed. Sarilumab, another IL-6 inhibitor, is indicated for the ...

Objective Evaluate open-label sarilumab monotherapy in patients with rheumatoid arthritis switching from adalimumab monotherapy in MONARCH (NCT02332590); assess long-term safety and efficacy in ...