The EMBO Journal20d
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in ...
thorax.bmj3mon
P152 Idiopathic pulmonary fibrosis related expression of cell extrusion genes within epithelial cell types
Cell types of focus included AT2, pan-endothelial, basal and dividing cells annotated with CellMarker2.0. Results A total of 74 cell extrusion-related genes that interacted with PIEZO1 were selected ...
The EMBO Journal20d
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
FdAT2 organoids are an attractive genetic model for understanding fundamental mechanisms of AT2 cell biology in health, and modeling inherited disorders and environmental insults which perturb their ...