What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

The central dogma of molecular biology suggests that the primary role of RNA is to convert the information stored in DNA into proteins. In reality, there is much more to the RNA story. However ...

Some RNA molecules, called ribozymes, possess catalytic activity and can catalyze chemical reactions. For example, the ribosome itself is a ribozyme, as the rRNA component catalyzes the formation of ...

Cells have a natural editing system that allows them to rearrange genetic instructions to create different proteins from the ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

Gliomas, a type of brain tumor, are notoriously difficult to treat due to their complex genetic makeup and ability to evade immune responses. In a recent study published in Nature, a research team ...

Rgenta Therapeutics, a clinical-stage biotechnology company pioneering the development of a new class of oral small molecules ...