Hyponatremia is a serum sodium concentration level of less than 135 mEq/L (< 135 mmole/L, SI) for at least 1 day (Kurokawa et al., 1996). A value of less than 120 mEq/L is considered a critical ...

The investigators subsequently monitored the long-term effects of dose-adjusted satavaptan treatment in the same group of patients with SIADH. Ten patients completed the 12-month open-label study ...