Xavier and colleagues collected tissue from the small intestine epithelium of mice and built transcriptional profiles using RNAseq. One of the striking revelations was the discovery of new subtypes of ...

Interestingly, the small intestine remained longer after ... They found that precursors of intestinal epithelial cells were rapidly growing in number and newly generated cells migrated faster ...

Epithelial cells form in the crypts of villi and migrate to the tips of the villi, where they are shed. This process is critical for maintaining the structure and function of the small intestine.

the epithelium undergoes rapid cellular turnover and regenerates continuously from multipotent intestinal stem cells (ISCs) present at the crypt base. During homeostasis, the ISC niche exists in the ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

Alcohol binge increases intestinal permeability ... levels in the proximal small intestine, triggering CB1R activation in intestinal epithelial cells. This activation disrupts tight junction ...