16). We tested the hypothesis that mutant APP causes age-dependent learning impairment through disruption of synaptic plasticity. Figure 2: LTP is impaired in the dentate gyrus in aged APP 695 SWE ...
The group focuses on studying the mechanisms guiding activity-dependent development of glutamatergic circuitry in the limbic system and in particular, the roles of ionotropic glutamate receptors in ...
The paper is titled "Focal clusters of peri-synaptic matrix contribute to activity-dependent plasticity and memory in mice." The work stems from a collaboration between the Harvard Medical School ...