This system incorporates a two-step T cell activation process that allows for highly precise tumor targeting and a controlled immune activation. Using the firearm analogy, Revitope opted to apply ...

Macrophages interact with T cells in order to bring about T cell activation in target organs, and are themselves activated by inflammatory ... medical therapy and so research in this project aims to ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

The researchers engineered cancer cells to re-express Parkin and found that Parkin contributes to the production of interferons, which activate and attract T cells to fight the tumor. The findings ...

they rely on activation from other immune cells, particularly antigen-presenting cells (APCs) such as dendritic cells—the main T cell activators. The process begins when cancer cells release ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Upon initial activation by their cognate antigen, naïve CD8 + T cells start to proliferate and differentiate into short-lived effector and long-lived memory precursor cells. How a single ...