This system incorporates a two-step T cell activation process that allows for highly precise tumor targeting and a controlled immune activation. Using the firearm analogy, Revitope opted to apply ...

Macrophages interact with T cells in order to bring about T cell activation in target organs ... so research in this project aims to reveal the details of this inflammatory process, with the long term ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

they rely on activation from other immune cells, particularly antigen-presenting cells (APCs) such as dendritic cells—the main T cell activators. The process begins when cancer cells release ...

Researchers at Cellectis leveraged gene editing to create a CAR T cell that acts in an IF/THEN system. Traditional methods to develop CAR T cells that use the patient’s cells introduce challenges ...

The researchers engineered cancer cells to re-express Parkin and found that Parkin contributes to the production of interferons, which activate and attract T cells to fight the tumor. The findings ...

Immune cells called regulatory T cells have long been known for their role in countering inflammation. In the setting of ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Researchers have designed process that uses ultrasound to modify the behavior of cancer-fighting T cells by increasing ... "The microbubbles can re-activate the cells that have been turned off ...