Despite their initial efficient response to induction chemotherapy, relapse remains frequent in patients with T-cell acute lymphoblastic leukemia (T-ALL), an aggressive malignancy of immature T ...

How do cells control gene expression to manage this potentially lethal dosage problem? A prime example of X inactivation is in the coat-color patterning of tortoiseshell or calico cats (Figure 1).

New research reveals that certain cells inactivate one parent’s copy of a gene, leading to a bias in gene activity that may ...