DCs have a central role in the activation of naive T cells and therefore ... The transport of peptide antigens across the lipid bilayers can principally occur either in a protein-dependent or ...

Projects in the laboratory focus on a range of specific processes that relate to; 1) maintenance and function of the marginal zone in the spleen and responses to blood borne pathogens, 2) initiation ...

Monoclonal antibodies (mAbs) may directly stall or kill tumour cells by binding tumour cell-specific antigens ... Acid-labile or pH-dependent linkers are designed to be stable at the relatively ...

Antigens targeted by chimeric antigen receptors CD19 ALL, CLL, B-cell NHL [78–80,89] CD20 CLL, B-cell NHL [153,154] CD22 CLL, B-cell NHL [155] CD23 CLL, B-cell NHL [156] CD30 Hodgkin's lymphoma ...

The recent achievement of durable engraftment of adoptively transferred T cells endowed with a CAR and costimulatory molecule provides an extraordinary opportunity to implement novel ...