DCs have a central role in the activation of naive T cells and therefore ... The transport of peptide antigens across the lipid bilayers can principally occur either in a protein-dependent or ...

initiation and maintenance of the germinal center reaction following challenge with T-dependent antigens, 3) the role of CD19 in regulating the duration of the primary humoral response and the ...

A stable interaction between antigen-presenting cells (APC) and T cells is dependent not only on the absolute affinity between the T-cell receptor (TCR) and its ligand but also on the relative ...

In this article, Cerba dives into CAR+ T-cell therapy, from patient treatment to solutions for minimal residual disease (MRD) ...

Antigens targeted by chimeric antigen receptors CD19 ALL, CLL, B-cell NHL [78–80,89] CD20 CLL, B-cell NHL [153,154] CD22 CLL, B-cell NHL [155] CD23 CLL, B-cell NHL [156] CD30 Hodgkin's lymphoma ...

The recent achievement of durable engraftment of adoptively transferred T cells endowed with a CAR and costimulatory molecule provides an extraordinary opportunity to implement novel ...