To get a better view of TGF-Beta moving in its straitjacket, the scientists methodically stabilized different parts of either ...

Select the journal/section where you want your idea to be submitted: The TGF-beta superfamily, encompassing molecules such as TGFs, activins, BMPs, GDFs, and Nodals, represents the largest family of ...

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and ...

The TGF-beta superfamily, encompassing molecules such as TGFs, activins, BMPs, GDFs, and Nodals, represents the largest family of growth and differentiation factors, playing crucial roles in ...

(“Keros” or the “Company”) (Nasdaq: KROS), a clinical-stage biopharmaceutical company focused on developing and ...

LEXINGTON, Mass., Jan. 15, 2025 (GLOBE NEWSWIRE) -- (“Keros” or the “Company”) (Nasdaq: KROS), a clinical-stage ...

This important work provides another layer of regulatory mechanism for TGF-beta signaling activity. The evidence supports the involvement of microtubules as a reservoir of Smad2/3, however, additional ...

Throughout his 30-year career, Dr. Massagué has been lauded for the originality and importance of his work elucidating the mechanism of action for transforming growth factor-beta (TGF-β) signaling.

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Mammary development is regulated temporally by hormones but spatially by local paracrine factors such as Wnts and TGF-beta. We have studied the roles of Wnt/beta-catenin and Hedgehog/Gli pathways in ...